2000 Ford Ranger Misfiring?

I've got a 2000 Ford ranger 3.0 v6 that starting misfiring pretty bad yesterday. I had the code read and it said cylinders 4 and 6 were misfiring. I just replaced the spark plugs and wires about 2 weeks ago and have been driving it everyday with no problems until yesterday. Any ideas on what is causing it to misfire? Should I replace the two wires and plugs again or could it be the ignition coil or what? Any help is appreciated.

Probably the coil pack.

Do not guess. Troubleshoot. Check for spark with a spark tester. Check if the injectors are firing or getting command to fire with a noid light. Check for compression with a gauge.

What kind of spark plugs did you use?
Ford's take Motorcraft plugs.

Coils 'wear-our' eventually, replace them