What parts are needed to do an engine tune up on a 2005 ford F150 Lariat with the 5.4 triton 4x4?

I bought a 2005 ford F150 and has 144,000 miles on it. It is running really rough, so i want to do a tune up on this. What is needed to do a full tune up on it, i mean down to the very part. Any advice for the best way to do it as well?

8 spark plugs. You'll want to get the redesigned one-piece plugs for the 3 valve 5.4L. You could throw in a new air filter, new fuel filter, oil change, and flush the radiator. But for a tune up these days, all you really do is replace the spark plugs. Keep in mind if it's on the original plugs at 144k miles, it's a near certainty that at least one or two will break when you try to remove them. That's even if you follow the prescribed methodology.

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