2004 new body style Ford F-150 throwing nock sensor code?

My 2005 Ford F-150 is throwing a code for a knock sensor however I'm thinking it is the transmission. Whenever I drive it it seems fine most of the time but if I flour it it will seem like it's misfiring. This is only when driving. It just now I had it in park and floured it and it did not misfire but 5 minutes ago when driving it it did when I floured it in between transmission shifts. The codes are P0325 and p0430. Anyone with a 5.4l 3v ford go through this also? Could it be my trans? Truck has a rebuilt motor which has been running fine but trans has almost 300k miles.

Check cat efficiency with a scanner and check the knock sensor circuit. Your truck's ECU is telling you what is wrong. Do not second guess it.

If the motor is misfiring it's going to throw a misfire code. It's probably not a transmission problem… It's happening under load. You need a $2000 mechanic's scan tool that can read engine data to determine if all the sensors are working with in spec.
What's the fuel pressure?
Check for vacuum leaks yet?
Lets see the fuel trim data.

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