Can I go to home depot to duplicate my car key for a 2008 Ford f-150?

Can I go to home depot to duplicate my car key for a 2008 Ford f-150?

Added (1). And if I do go to home depot for a duplicate, will it start my car?

Probably. Be aware that if the key is a remote version there will be a very small chip inside that needs transferring to the new case.

Depends if Lowes has the duplicate that has a chip in it. Then you'll need to have the dealer program the chip to the car

Sure you can but I don't know what you will do about the chip that should be there.
On your update, without the chip it will not start the car.

You can, but there will be no chip in it so will only unlock the doors. You need a dealer key for ingnition.