What should I change my diff gears to for highway use?

I have a old 1971 ford f250, witch is great other then the gearing is way to low. On the highway going about 55 the rpm is around 3200 and at 80 I think its 4000-4500 when its in 4th gear. I don't even use 1st gear at all cus its so slow. The diff ratio right now is a 4:1 I would like to be at 2200 rpm at 80mph in 4th gear but can't find a clear answer as to what I should change the ratio to.

Added (1). I typed the question a bit fast, I mean what would work best that well allow me to travel on the freeway comfortably.

Added (2). sorry the ratio is also 3.25

It's a simple ratio thing. Half the ratio half the engine speed for the same road speed. Work out what revs you want for 80 mph. (doubt it would hold 80 at 2200 rpm.)
Before you spend day agonizing over it find out what ratios are available & how much it will cost.

There's a lot more to change.
You need to change your speedometer drive as well or it will read very wrong.

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