What is a good car for a cross country road trip?

I'm a 17 year old male and in high school (graduating ths year). I'm planning on going to college in California. I'm from NY. I currently have a pickup truck. I'm looking to sell that and get a mid-full size sedan (NO compacts/hatchbacks). What would be the most comfortable and fuel efficient?

Added (1). Some of the cars I was considering:
-Ford Fusion
-Ford Taurus
-Mercury Milan
-Ford Five-Hundred
-Cadillac DTS

Added (2). Unfortunately, I can't afford something new.

Added (3). I'm also thinking about the Lincoln Town Car.

Well, Subaru Legacy was chosen as the best mid-size sedan in 2015. True, it's now not the only one to offer AWD, but it remains the best and the most affordable. Other positives are the Legacy's history of reliability and strong resale value. The Subaru Legacy has always stood out with its traction-enhancing all-wheel drive. With a more appealing design, far better technology and improved fuel efficiency, the new Legacy is a legitimate contender among family sedans.

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